Being overweight ... might not be entirely your fault. Source: ThinkStock
FAT mothers could be damaging their babies and placing them at risk of obesity even before they conceive, a new study shows.
The Adelaide University study has found obesity damages eggs and the mitochondria responsible for energy regulation and metabolism.
However, the breakthrough new study shows this obesity risk can be reversed and the fertility of obese women improved by a new drug being tested for use in diabetes.
University of Adelaide Professor Rebecca Robker hopes the findings can help prevent obesity being passed from one generation to the next.
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New research ... your risk of obesity begins even before you are conceived. Picture: Thinkstock Source: News Limited
The study harvested eggs from obese mice and found they had less mitochondrial DNA.
The eggs were fertilised using IVF procedures and were then implanted into normal sized mice to grow.
"We found that the foetuses from the eggs of such (obese) mothers led to heavier than normal foetuses with greatly reduced amounts of mitochondrial DNA and other obvious signs of damage," Professor Robker said.
"It is becoming clear that the risk of obesity is determined even before conception," she said.
"Women think, I'm pregnant and now I'll start being healthy but the nutritional signs of obesity are in the eggs even before they are fertilised," she said.
Scientists involved in the study published by The Company of Biologists found that obesity led to a stress response that caused damage to mitochondria, energy producing organs in cells.
They fed obese mice two compounds known to alleviate that stress in the cells for four days before they harvested their eggs.
It's too late ... for mums to start getting healthy after they get pregnant. Picture: Thinkstock Source: News Limited
Both the compounds were successful in preventing the stress and the damage from obesity being passed onto the baby, Professor Robker said.
One of the compounds can't be used in humans because it can promote stress in some people but the other was a compound BGP15 being trialled to restore cellular damage in humans caused by diabetes.
The study found the use of the compound also helped the fertility of the obese mice, improving their ability to ovulate.
This could indicate the compound might be able to help obese women who are having trouble getting pregnant naturally, Professor Robker said.
"Importantly this work further highlights that a woman's nutritional state prior to getting pregnant matters greatly," she said.
"Women are urged to eat healthy diets and optimise their chances for a healthy conception and to reduce the potential impact on their child's future health," she said,
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